Ep. 302 - Breaking: 4 Hidden Types of Insulin Resistance Revealed | Personalized Fasting Strategy Based on Your Metabolic Subtype | Why One-Size-Fits-All Fasting Fails | Stanford Research Decoded | New Fasting Persona Quiz!
This groundbreaking episode unveils Stanford Professor Michael Snyder's revolutionary research published in Nature Biomedical Engineering revealing that type 2 diabetes and insulin resistance aren't single diseases but four distinct metabolic subtypes requiring personalized fasting and nutrition strategies. The hosts decode how muscle insulin resistance demands early time-restricted eating with 18:6 or OMAD plus resistance training, beta cell dysfunction requires gentle 16:8 fasting while avoiding extended fasts to prevent pancreatic burnout, impaired incretin effect needs pre-meal walking with fermented foods to enhance gut hormone signaling, and liver glucose dysregulation necessitates 30-36 hour fasts weekly to reset hepatic insulin resistance and stop the liver's continuous glucose output. Dr. Scott and Tommy explain why A1C measurements provide almost no insight into underlying mechanisms, with individuals showing normal A1C yet severe insulin resistance while others display pre-diabetic A1C with preserved insulin sensitivity, making traditional one-size-fits-all weight loss recommendations fundamentally flawed. The episode introduces at-home oral glucose tolerance testing to decode personal glucose curves and identify specific pathology, while emphasizing foundational recommendations—early meals, resistance training, post-meal walks, protein prioritization, sleep protection, and stress management—move the needle for most people regardless of subtype, with personalized optimization becoming critical for those stuck despite consistent effort.
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Article Links: https://www.nature.com/articles/s41551-024-01311-6